Diethyl Ether → HCID 54327587, compound

HRID 974305Notes

Reaction equation

HRID 974305 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[CH:12]=[CH:13][CH2:14]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:19][C:20]1[S:21][C:22]2[CH2:23][CH2:24][NH:25][CH2:26][CH2:27][C:28]=2[N:29]=1.CCOCC>C(Cl)(Cl)Cl>[NH2:19][C:20]1[S:21][C:22]2[CH2:23][CH2:24][N:25]([CH2:14][CH:13]=[CH:12][C:11]3[CH:16]=[CH:17][CH:18]=[C:9]([O:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH:10]=3)[CH2:26][CH2:27][C:28]=2[N:29]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 54206840HCID 54206840, compound

Product 1

HCID 54327587HCID 54327587, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 3-benzyloxy-cinnamyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6 H-thiazolo[5,4-d]azepine in chloroform for 5 hours at 50° C. Yield: 59% of theory, Melting point: 78°-80° C. (ether).

Sources & evidence

ORD record
ord-7c1e6ee626be4be6861e104f5f41c37d
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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