Acetone → HCID 86745242, compound

HRID 974323Notes

Reaction equation

HRID 974323 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:12][C:13]#[C:14][C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)[CH2:8][CH2:9][C:10]=2[N:11]=1.CC(C)=O>C(O)C.[Pd].S([O-])([O-])(=O)=O.[Ba+2]>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:12]/[CH:13]=[CH:14]\[C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)[CH2:8][CH2:9][C:10]=2[N:11]=1

Participants

5

Reactant 2

HCID 180AcetoneHCID 19985806HCID 19985806, compound

Product 1

HCID 86745242HCID 86745242, compoundYield 42%

Reagents, catalysts & solvents 2

HCID 16218511Pd barium sulfateCatalystHCID 702EthanolSolvent

Procedure

Prepared by catalytic hydrogenation of 2-amino-6 -(3-(3-pyridyl)-2-propyn-1-yl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine with palladium/barium sulphate (5%) in ethanol. Yield: 42% of theory, Melting point: 125°-126° C. (acetone).

Sources & evidence

ORD record
ord-157bbe03b0b24f5f8ee5aaf7688deb47
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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