Sodium cyanoborohydride → HCID 53673269, compound

HRID 974325Notes

Reaction equation

HRID 974325 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][CH:11]=O)=[CH:5][CH:4]=1)#[N:2].[NH2:13][C:14]1[S:15][C:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21][C:22]=2[N:23]=1.C([BH3-])#N.[Na+]>>[NH2:13][C:14]1[S:15][C:16]2[CH2:17][CH2:18][N:19]([CH2:11][CH:10]=[CH:9][C:6]3[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=3)[CH2:20][CH2:21][C:22]=2[N:23]=1

Participants

4

Reactant 3

HCID 5003444Sodium cyanoborohydrideHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 54292473HCID 54292473, compound

Product 1

HCID 53673269HCID 53673269, compoundYield 8%

Procedure

Prepared from 3-(4-cyano-phenyl)acrolein and 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine by reductive amination with sodium cyanoborohydride. Yield: 8% of theory, Melting point: 199°-205° C. (decomp).

Sources & evidence

ORD record
ord-e0905e55c86342ef8b5dfff4d0afffbc
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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