Diethyl Ether → HCID 54375116, compound

HRID 974328Notes

Reaction equation

HRID 974328 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:12][CH:13]=[CH:14][C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([O:21]CC4C=CC=CC=4)[CH:16]=3)[CH2:8][CH2:9][C:10]=2[N:11]=1.B(Br)(Br)Br.CCOCC>C(Cl)Cl>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:12][CH:13]=[CH:14][C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([OH:21])[CH:16]=3)[CH2:8][CH2:9][C:10]=2[N:11]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 25134Boron tribromideHCID 54327587HCID 54327587, compound

Product 1

HCID 54375116HCID 54375116, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from 2-amino-6-(3-(3-benzyloxy-phenyl)allyl)-4,5,7,8-tetrahydro-6H- thiazolo[5,4-d]azepine with 2 equivalents of boron tribromide in methylene chloride. Yield: 71% of theory, Melting point: 85°-95° C. (ether); foamy.

Sources & evidence

ORD record
ord-80801ff0fbdf4db5b5fa16fc0e2e8275
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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