HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86745245, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | HCID 19985760 | HCID 19985760 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Lindlars catalyst | HCID 131709914 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86745245 | HCID 86745245 | 29.5% |
Reaction Steps
Prepared analogously to Example 12 by catalytic hydrogenation of 1.30 g (4.21 mmol) of 2-amino-6-(3-(4-cyano-phenyl)-2-propyn-1-yl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine. 0.3 H2O in anhydrous dimethylformamide under 1 bar of hydrogen pressure using Lindlar catalyst (5% palladium on calcium carbonate, contaminated with lead) at ambient temperature. Yield: 29.5% of theory, Melting point: 186°-188° C. (ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05068325 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-0d2086d4127b4b04b61c8982a4d75727 |
| Source note | uspto-grants-1991_11 |