反应详情

Prepared analogously to Example 12 by catalytic hydrogenation of 2-amino-6-(3-(2-oxo-indolin-4-yl)-2-propyn-1-yl)-4,5,7,8-tetrahydro-6H- thiazolo[5,4-d]azepine. 0.75 H2O using Lindlar catalyst (palladium on calcium carbonate, contaminated with lead) for 3 hours at ambient temperature in ethanol. Yield: 51% of theory, Melting point: 192°-195° C. (acetone/ether).

1. customfor 3 hours
2. customat ambient temperature