Water → HCID 86745246, compound

HRID 974345Notes

Reaction equation

HRID 974345 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:12][C:13]#[C:14][C:15]3[CH:23]=[CH:22][CH:21]=[C:20]4[C:16]=3[CH2:17][C:18](=[O:24])[NH:19]4)[CH2:8][CH2:9][C:10]=2[N:11]=1.O.CC(C)=O.CCOCC>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2].C(O)C>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:12]/[CH:13]=[CH:14]\[C:15]3[CH:23]=[CH:22][CH:21]=[C:20]4[C:16]=3[CH2:17][C:18](=[O:24])[NH:19]4)[CH2:8][CH2:9][C:10]=2[N:11]=1

Participants

6

Reactant 3

HCID 962WaterHCID 19985707HCID 19985707, compoundHCID 21584533Acetone diethylether

Product 1

HCID 86745246HCID 86745246, compoundYield 51%

Reagents, catalysts & solvents 2

HCID 131709914Lindlars catalystCatalystHCID 702EthanolSolvent

Procedure

Prepared analogously to Example 12 by catalytic hydrogenation of 2-amino-6-(3-(2-oxo-indolin-4-yl)-2-propyn-1-yl)-4,5,7,8-tetrahydro-6H- thiazolo[5,4-d]azepine. 0.75 H2O using Lindlar catalyst (palladium on calcium carbonate, contaminated with lead) for 3 hours at ambient temperature in ethanol. Yield: 51% of theory, Melting point: 192°-195° C. (acetone/ether).

Workup

  1. customfor 3 hours
  2. customat ambient temperature

Sources & evidence

ORD record
ord-c17623634616473cb98e822881413b16
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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