HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86745246, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 19985707 | HCID 19985707 | — |
| Reactant | Acetone diethylether | HCID 21584533 | — |
| Catalyst | Lindlars catalyst | HCID 131709914 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 86745246 | HCID 86745246 | 51% |
Reaction Steps
Prepared analogously to Example 12 by catalytic hydrogenation of 2-amino-6-(3-(2-oxo-indolin-4-yl)-2-propyn-1-yl)-4,5,7,8-tetrahydro-6H- thiazolo[5,4-d]azepine. 0.75 H2O using Lindlar catalyst (palladium on calcium carbonate, contaminated with lead) for 3 hours at ambient temperature in ethanol. Yield: 51% of theory, Melting point: 192°-195° C. (acetone/ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05068325 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-c17623634616473cb98e822881413b16 |
| Source note | uspto-grants-1991_11 |