2,5-Dimethoxytetrahydrofuran → HCID 18972360, compound

HRID 974388Notes

Reaction equation

HRID 974388 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].CO[CH:13]1[CH2:17][CH2:16][CH:15](OC)O1>>[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4][N:5]1[CH:13]=[CH:17][CH:16]=[CH:15]1

Participants

3

Reactant 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 27332442,4-Difluorobenzylamine

Product 1

HCID 18972360HCID 18972360, compound

Procedure

8.6 g (0.060 mol) of 2,4-difluorobenzylamine are heated in an autoclave with 8 g (0.060 mol) of 2,5-dimethoxytetrahydrofuran for 2 hours at 250° C. The reaction mixture is cooled and then purified by vacuum distillation. 9.2 g (79% of theory) of a colourless oil which boils at 110°-114° C. at 16 mbar are obtained.

Workup

  1. temperatureThe reaction mixture is cooled
  2. distillationpurified by vacuum distillation
  3. custom9.2 g (79% of theory) of a colourless oil which boils at 110°-114° C. at 16 mbar are obtained

Sources & evidence

ORD record
ord-b6de5b098cbb4f6f89e8fc2cda5786bc
Source dataset
uspto-grants-1991_11
Patent number
US05068371

Reaction notes

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