HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dimethoxytetrahydrofuran → 1-[(2,4-Difluorophenyl)methyl]-1H-pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| Reactant | 2,4-Difluorobenzylamine | HCID 2733244 | — |
| Product | 1-[(2,4-Difluorophenyl)methyl]-1H-pyrrole | HCID 18972360 | — |
Reaction Steps
8.6 g (0.060 mol) of 2,4-difluorobenzylamine are heated in an autoclave with 8 g (0.060 mol) of 2,5-dimethoxytetrahydrofuran for 2 hours at 250° C. The reaction mixture is cooled and then purified by vacuum distillation. 9.2 g (79% of theory) of a colourless oil which boils at 110°-114° C. at 16 mbar are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05068371 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-b6de5b098cbb4f6f89e8fc2cda5786bc |
| Source note | uspto-grants-1991_11 |