反应详情

A solution of 3 g (1-cyanocyclohexyl)-acetic acid in 10.5 mL methanol is hydrogenated at 10 bar hydrogen pressure and 30° C. in the presence of rhodium-carbon (5%) over a period of five hours. The reaction mixture is filtered and the filtrate evaporated on a rotary evaporator at 30° C. The crystalline residue is stirred with isopropanol and the crystallizate is filtered off with suction and dried to constant weight in a vacuum drying cabinet at 30° C. 2.0 g of the title compound are obtained (65.2% of theory); m.p. 152° C.

1. filtrationThe reaction mixture is filtered
2. customthe filtrate evaporated on a rotary evaporator at 30° C
3. filtrationthe crystallizate is filtered off with suction
4. customdried to constant weight in a vacuum
5. customdrying cabinet at 30° C