Thiazole → HCID 67870464, compound

HRID 974680Notes

Reaction equation

[P:1]([O-:39])([O:35][CH2:36][CH2:37]Br)([O:3][CH2:4][CH:5]([O:29][C:30]1[CH:34]=[CH:33][O:32][N:31]=1)[CH2:6][O:7][C:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[O:10][N:9]=1)=[O:2].[S:40]1[CH:44]=[CH:43][N:42]=[CH:41]1>>[P:1]([O-:39])([O:35][CH2:36][CH2:37][C:41]1[S:40][CH:44]=[CH:43][NH+:42]=1)([O:3][CH2:4][CH:5]([O:29][C:30]1[CH:34]=[CH:33][O:32][N:31]=1)[CH2:6][O:7][C:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[O:10][N:9]=1)=[O:2]

Participants

Reactant 2

HCID 9256Thiazole

HCID 19986072HCID 19986072, compound

Product 1

HCID 67870464HCID 67870464, compound

Procedure

0.779 g of (2RS)-3-(5-hexadecyl-3-isoxazolyloxy)-2-(3-isoxazolyloxy)propyl 2-bromoethyl phosphate [prepared as described in Example 21(a)] was reacted with 0.86 ml of thiazole in a similar manner to that described in Example 13, to give 0.288 g of the title compound as a white powder melting at 94°-100° C.

Sources & evidence

ORD record: ord-153d846c917b46deb9d879a69f729bc7
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05068340

Reaction notes

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