Thiazole → HCID 19986111, compound

HRID 974683Notes

Reaction equation

[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:41])[O:9][CH2:10][CH:11]([O:34][C:35]1[CH:39]=[C:38]([CH3:40])[O:37][N:36]=1)[CH2:12][O:13][C:14](=[O:33])[NH:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32].[S:42]1[CH:46]=[CH:45][N:44]=[CH:43]1>>[Br-:1].[CH2:16]([NH:15][C:14]([O:13][CH2:12][CH:11]([O:34][C:35]1[CH:39]=[C:38]([CH3:40])[O:37][N:36]=1)[CH2:10][O:9][C:8]([NH:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][N+:44]1[CH:45]=[CH:46][S:42][CH:43]=1)=[O:41])=[O:33])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]

Participants

Reactant 2

HCID 9256Thiazole

HCID 19986104HCID 19986104, compound

Product 1

HCID 19986111HCID 19986111, compound

Procedure

33(b) 0.388 g of the title compound was prepared, as a powder, by reacting 0.600 g of (2RS)-3-(N-heptadecylcarbamoyloxy)-2-(5-methyl-3-isoxazolyloxy)propyl N-(5-bromopentyl)carbamate [prepared as described in step (a) above] with 0.66 ml of thiazole by a similar procedure to that described in Example 25(b).

Sources & evidence

ORD record: ord-ceb1bfad28604d24a1fc4971bd973aa3
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05068340

Reaction notes

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