Choline → HCID 86750432, compound

HRID 974766Notes

Reaction equation

HRID 974766 reaction equation
[OH:1][CH2:2][CH2:3][N+:4]([CH3:7])([CH3:6])[CH3:5].[C:8]([Cl:11])([Cl:10])=[O:9]>C1COCC1>[Cl:11][C:8]([O-:9])=[O:1].[Cl-:10].[OH:1][CH2:2][CH2:3][N+:4]([CH3:7])([CH3:6])[CH3:5].[OH:1][CH2:2][CH2:3][N+:4]([CH3:7])([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 305CholineHCID 6371Phosgene

Product 1

HCID 86750432HCID 86750432, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of choline (2.235 mg, 16 mmol) and phosgene (32 ml, 1.93M in toluene) in THF (90 ml) was stirred at room temperature for 72 hours. The precipitate was filtered, washed with hexane, and dried in vacuo to yield choline chloride chloroformate (3.0 g).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with hexane
  3. customdried in vacuo

Sources & evidence

ORD record
ord-d59b057dcf9e4de1b4d630a0b4e2776f
Source dataset
uspto-grants-1997_03
Patent number
US05607691

Reaction notes

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