反应详情

温度

130 °C

A mixture of 5-methoxy-1-tetralone (1 g; 5.67 mmol), thiophene-2-carboxaldehyde (800 μl 8.51 mmol), piperidine (168 μl; 1.7 mmol) and acetic acid (97 μl; 1.7 mmol) was heated at 130° C. for 2 hours. The mixture was taken up in CH2C2 and washed in water and in a saturated aqueous solution of NaCl. The organic phase was dried over MgSO4, filtered and evaporated. The residue was purified by flash chromatography on silica gel, eluting with petroleum ether/ethyl acetate (95/5) to give 5-methoxy-2-(2-thienylmethylene)-1-tetralone (1.2 g; 80%)

1. washwashed in water and in a saturated aqueous solution of NaCl
2. dry with materialThe organic phase was dried over MgSO4
3. filtrationfiltered
4. customevaporated
5. customThe residue was purified by flash chromatography on silica gel
6. washeluting with petroleum ether/ethyl acetate (95/5)