反应详情

A mixture of 6-hydroxychromone (4.5 g; 27.7 mmol), CH2Cl2 (150 ml), water (150 ml), dimethylsulphate (4 ml; 41.5 mmol), benzyltributylammmonium bromide (2 g; 5.5 mmol) and NaHCO3 (1.67 g; 41.5 mmol) was stirred for 24 hours at ambient temperature. The organic phase was decanted, washed with water, a dilute solution of ammonium hydroxide and with 1N HCl, it was dried over MgSO4 and evaporated. It was purified by chromatography, eluting with ethyl acetate/petroleum ether (50/50) to give 6-methoxychromone (4 g; 83%) as a brown solid.

1. customThe organic phase was decanted
2. washwashed with water
3. dry with materiala dilute solution of ammonium hydroxide and with 1N HCl, it was dried over MgSO4
4. customevaporated
5. customIt was purified by chromatography
6. washeluting with ethyl acetate/petroleum ether (50/50)