HCID 14118983, compound → HCID 19969441, compound

HRID 974811Notes

Reaction equation

HRID 974811 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[NH:10][C:9](=[O:18])[C:8]=2[CH:19]=1)([O-])=O>C(O)(=O)C.O=[Pt]=O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[NH:10][C:9](=[O:18])[C:8]=2[CH:19]=1

Participants

4

Reactant 1

HCID 14118983HCID 14118983, compound

Product 1

HCID 19969441HCID 19969441, compoundYield 65.8%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 176Acetic AcidSolvent

Procedure

2-Nitro-10,11-dihydrodibenzo[b,f][1,4]thiazepin-11-one (0.82 g) was dissolved in warm acetic acid (100 ml) and the resulting solution hydrogenated over Adam's catalyst (80 g) for 3 hours at atmospheric pressure. The catalyst was filtered off and the solution evaporated to dryness. Recrystallisation of the residue from methanol gave the product as a greenish powder (0.48 g, m/s, M+ =242).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solution evaporated to dryness
  3. customRecrystallisation of the residue from methanol

Sources & evidence

ORD record
ord-74350844bd484f09bbbac3206604f022
Source dataset
uspto-grants-1997_03
Patent number
US05607929

Reaction notes

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