Sodium → HCID 178502777, compound

HRID 974872Notes

Reaction equation

[NH2:1][C:2]1[S:6][N:5]=[C:4](/[C:7](=[N:45]/[O:46][CH3:47])/[C:8]([NH:10][CH:11]2[C:43](=[O:44])[N:13]3[C:14]([C:27]([O:29]C(C4C=CC=CC=4)C4C=CC=CC=4)=[S:28])=[C:15]([C:18]4[S:19][C:20]5[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=5[N:22]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1.[Na]>>[NH2:1][C:2]1[S:6][N:5]=[C:4](/[C:7](=[N:45]/[O:46][CH3:47])/[C:8]([NH:10][CH:11]2[C:43](=[O:44])[N:13]3[C:14]([C:27]([OH:29])=[S:28])=[C:15]([C:18]4[S:19][C:20]5[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=5[N:22]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1

Participants

Reactant 2

HCID 5360545Sodium

HCID 141564111HCID 141564111, compound

Product 1

HCID 178502777HCID 178502777, compoundYield 55.5%

Procedure

Using 324 mg of diphenylmethyl 7-{(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido}-3-(benzothiazol-2-yl)thio-3-cephem-4-carboxylate, the reaction and purification process of Inventive Example 1 (d) was repeated to obtain 137 mg of the title compound as a sodium salt (yield, 64%).

Sources & evidence

ORD record: ord-80e51fa821d64d059f48598ce366be21
Source dataset: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05607927

Reaction notes

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