Sodium → HCID 178502778, compound

HRID 974873Notes

Reaction equation

HRID 974873 reaction equation
[NH2:1][C:2]1[S:6][N:5]=[C:4](/[C:7](=[N:45]/[O:46][CH3:47])/[C:8]([NH:10][CH:11]2[C:43](=[O:44])[N:13]3[C:14]([C:27]([O:29]C(C4C=CC=CC=4)C4C=CC=CC=4)=[S:28])=[C:15]([C:18]4[S:19][C:20]5[C:25]([N:26]=4)=[CH:24][CH:23]=[CH:22][N:21]=5)[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1.[Na]>>[NH2:1][C:2]1[S:6][N:5]=[C:4](/[C:7](=[N:45]/[O:46][CH3:47])/[C:8]([NH:10][CH:11]2[C:43](=[O:44])[N:13]3[C:14]([C:27]([OH:29])=[S:28])=[C:15]([C:18]4[S:19][C:20]5[C:25]([N:26]=4)=[CH:24][CH:23]=[CH:22][N:21]=5)[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1

Participants

3

Reactant 2

HCID 5360545SodiumHCID 141564109HCID 141564109, compound

Product 1

HCID 178502778HCID 178502778, compoundYield 73.2%

Procedure

Using 335 mg of diphenylmethyl 7-{(Z)-2-(5-amino1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido}-3-(thiazolo[5,4-b]pyridin-2-yl)thio-3-cephem-4-carboxylate, the reaction and purification process of Inventive Example 1 (d) was repeated to obtain 187 mg of the title compound as a sodium salt (yield, 70%).

Sources & evidence

ORD record
ord-5c247550b36c4e79aff54f40126c5a69
Source dataset
uspto-grants-1997_03
Patent number
US05607927

Reaction notes

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