反应详情

A solution of 4 g (18.2 mmol) of 8-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane in 100 ml of methanol and 3.5 ml of concentrated hydrochloric acid is hydrogenated on 2 g of palladium-on-active charcoal (10% of Pd) at 80° C. under 100 bar. The catalyst is filtered off and washed with water. The filtrates are concentrated and the product is crystallized by trituration with a little methanol. The crystals are filtered off with suction, washed with acetone and dried in air.

1. filtrationThe catalyst is filtered off
2. washwashed with water
3. concentrationThe filtrates are concentrated
4. customthe product is crystallized by trituration with a little methanol
5. filtrationThe crystals are filtered off with suction
6. washwashed with acetone
7. customdried in air