Hydrochloric Acid → HCID 19594629, compound

HRID 974891Notes

Reaction equation

HRID 974891 reaction equation
C([N:8]1[CH2:16][CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][O:14]2)[CH2:9]1)C1C=CC=CC=1.[ClH:17]>CO.[Pd]>[ClH:17].[ClH:17].[CH:15]12[CH2:16][NH:8][CH2:9][CH:10]1[NH:11][CH2:12][CH2:13][O:14]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

Product 1

HCID 19594629HCID 19594629, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 4 g (18.2 mmol) of 8-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane in 100 ml of methanol and 3.5 ml of concentrated hydrochloric acid is hydrogenated on 2 g of palladium-on-active charcoal (10% of Pd) at 80° C. under 100 bar. The catalyst is filtered off and washed with water. The filtrates are concentrated and the product is crystallized by trituration with a little methanol. The crystals are filtered off with suction, washed with acetone and dried in air.

Workup

  1. filtrationThe catalyst is filtered off
  2. washwashed with water
  3. concentrationThe filtrates are concentrated
  4. customthe product is crystallized by trituration with a little methanol
  5. filtrationThe crystals are filtered off with suction
  6. washwashed with acetone
  7. customdried in air

Sources & evidence

ORD record
ord-cb36726adaa84de2b616fdea56bf1283
Source dataset
uspto-grants-1997_03
Patent number
US05607942

Reaction notes

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