Water → 8-Benzyl-5-methyl2-oxa-5,8-diazabicyclo[4.3.0]nonane

HRID 974894Notes

Reaction equation

HRID 974894 reaction equation
[CH2:1]([N:8]1[CH2:12][CH:11](O)[CH:10]([N:14]([CH2:16][CH2:17][OH:18])[CH3:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O>S(=O)(=O)(O)O>[CH2:1]([N:8]1[CH2:12][CH:11]2[CH:10]([N:14]([CH3:15])[CH2:16][CH2:17][O:18]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 962WaterHCID 199698261-Benzyl-4-hydroxy-3-(2-hydroxyethylmethyl-amino)-pyrrolidine

Product 1

HCID 150699848-Benzyl-5-methyl2-oxa-5,8-diazabicyclo[4.3.0]nonane

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

18 g (71.9 mmol) of 1-benzyl-4-hydroxy-3-(2-hydroxyethyl-methyl-amino)-pyrrolidine are reacted in 60 ml of concentrated sulphuric acid and 30 ml of water as in Example F a).

Sources & evidence

ORD record
ord-3e72ae7a181043d4b3fa48ac57d6a463
Source dataset
uspto-grants-1997_03
Patent number
US05607942

Reaction notes

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