HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethylamine → trans-1-Benzyl-3-benzylmethylamino-4-hydroxypyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | 3-Benzyl-6-oxa-3-azabicyclo(3.1.0)hexane | HCID 9815370 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | trans-1-Benzyl-3-benzylmethylamino-4-hydroxypyrrolidine | HCID 69706831 | — |
Reaction Steps
19.4 g (0.1 mol) of 90% strength 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated under reflux with 14.5 g (0.12 mol) of benzylmethylamine in 100 ml of dioxane and 200 ml of water overnight. The mixture is extracted with CHCl3, the extracts are dried with K2CO3 and concentrated and the residue is subjected to incipient distillation up to 160° C. (oil bath temperature).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607942 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-a0a3e4bef1094b96853f1de1984f3d36 |
| Source note | uspto-grants-1997_03 |