反应详情

19.4 g (0.1 mol) of 90% strength 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated under reflux with 14.5 g (0.12 mol) of benzylmethylamine in 100 ml of dioxane and 200 ml of water overnight. The mixture is extracted with CHCl3, the extracts are dried with K2CO3 and concentrated and the residue is subjected to incipient distillation up to 160° C. (oil bath temperature).

1. extractionThe mixture is extracted with CHCl3
2. dry with materialthe extracts are dried with K2CO3
3. concentrationconcentrated
4. distillationdistillation up to 160° C. (oil bath temperature)