HCID 131719886, compound → HCID 131719884, compound

HRID 974987Notes

Reaction equation

HRID 974987 reaction equation
[ClH:1].[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]([NH:16][CH:17]3[CH2:22][CH2:21][N:20]([CH2:23][C:24]([O:26]C)=[O:25])[CH2:19][CH2:18]3)[S:14][CH:15]=2)=[CH:7][CH:6]=1>Cl>[ClH:1].[ClH:1].[ClH:1].[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]([NH:16][CH:17]3[CH2:18][CH2:19][N:20]([CH2:23][C:24]([OH:26])=[O:25])[CH2:21][CH2:22]3)[S:14][CH:15]=2)=[CH:7][CH:6]=1

Participants

3

Reactant 1

HCID 131719886HCID 131719886, compound

Product 1

HCID 131719884HCID 131719884, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

1 g of methyl (4-{4-[4-(aminoiminomethyl)phenyl]-1,3-thiazol-2-ylamino}piperid-1-yl)acetate hydrochloride (EXAMPLE 1) is added to 20 ml of 6N hydrochloric acid and the reaction mixture is heated under reflux for 5 hours. The mixture is evaporated to dryness and the residue is crystallized from acetone to give white crystals which melt at 216° C.; yield: 96%.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureunder reflux for 5 hours
  3. customThe mixture is evaporated to dryness
  4. customthe residue is crystallized from acetone
  5. customto give white crystals which
  6. custommelt at 216° C.

Sources & evidence

ORD record
ord-ef5a47e6fc274d7eb36963e30551ace0
Source dataset
uspto-grants-1997_03
Patent number
US05607952

Reaction notes

Loading…