Hydrochloric Acid → HCID 70128117, compound

HRID 974988Notes

Reaction equation

HRID 974988 reaction equation
[ClH:1].[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]([N:16]([CH2:29][CH2:30][C:31]([O:33]CC)=[O:32])[CH:17]3[CH2:22][CH2:21][N:20]([CH2:23][C:24]([O:26]CC)=[O:25])[CH2:19][CH2:18]3)[S:14][CH:15]=2)=[CH:7][CH:6]=1.Cl>>[ClH:1].[ClH:1].[ClH:1].[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]([N:16]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])[CH:17]3[CH2:22][CH2:21][N:20]([CH2:23][C:24]([OH:26])=[O:25])[CH2:19][CH2:18]3)[S:14][CH:15]=2)=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67703502HCID 67703502, compound

Product 1

HCID 70128117HCID 70128117, compoundYield 80%

Procedure

700 mg of ethyl 3-[N-{4-[4-(aminoiminomethyl)phenyl]-1,3-thiazol-2-yl}-N-(1-ethoxycarbonylmethyl-piperid-4-yl)amino]propionate hydrochloride (EXAMPLE 2) are added to 25 ml of 6N hydrochloric acid and the reaction mixture is heated under reflux for 5 hours. The mixture is evaporated to dryness and the residue is crystallized from acetone to give white crystals which melt at 215° C.; yield: 80%.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureunder reflux for 5 hours
  3. customThe mixture is evaporated to dryness
  4. customthe residue is crystallized from acetone
  5. customto give white crystals which
  6. custommelt at 215° C.

Sources & evidence

ORD record
ord-e42ddc10a06742a8932cd34821694f13
Source dataset
uspto-grants-1997_03
Patent number
US05607952

Reaction notes

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