反应详情

6.03 g of the hydrochloride was suspended into 100 ml of acetonitrile, to which 4.79 g of 2-(3,4-dimethoxyphenyl) ethyl chloride, 8.24 g of anhydrous potassium carbonate and n-tetrabutyl ammonium iodide (catalytic amount) were added and refluxed under heating for 20 hours. After allowing them to cool, the inorganic salts were filtered out and the solvent was distilled off. After adding ethyl acetate and washed with water, they were dried with anhydrous magnesium sulfate. The solvent was concentrated and purified on silica gel chromatography to obtain 1.03 g of the above-captioned compound (total yield: 6.5%).

1. additionwere added
2. temperaturerefluxed
3. temperatureunder heating for 20 hours
4. temperatureto cool
5. filtrationthe inorganic salts were filtered out
6. distillationthe solvent was distilled off
7. additionAfter adding ethyl acetate
8. washwashed with water, they
9. dry with materialwere dried with anhydrous magnesium sulfate
10. concentrationThe solvent was concentrated
11. custompurified on silica gel chromatography