HRID975028

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID702

Ethanol

C2H6O

2 次

HCID1110

Butanedioic acid

C4H6O4

结构：CN1CCC[C@@H]1Cc1c[nH]c2ccc(CCS(=O)(=O)c3ccccc3)cc12

HCID77993

Eletriptan

C22H26N2O2S

PRODUCTS

生成物

结构：CN1CCC[C@@H]1Cc1c[nH]c2ccc(CCS(=O)(=O)c3ccccc3)cc12.CN1CCC[C@@H]1Cc1c[nH]c2ccc(CCS(=O)(=O)c3ccccc3)cc12.O=C(O)CCC(=O)O

HCID131719487

未命名化合物

收率 95.7%

PROCEDURE

实验过程

A solution of succinic acid (95 mg) in ethanol (5 mL) was added to a solution of (R)-5-(2-benzenesulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole free base (620 mg) in ethanol (5 mL). The solution was evaporated to give the title compound as a foam (680 mg): [α]25D =+29° (methanol, c=0.10). Anal. Calcd for C22H26N2O2S. 0.5 C4H6O4. 0.33 C2H5OH. 0.5 H2O; C, 63.59; H, 6.92; N, 6.01. Found: C, 63.52; H, 6.91; N, 6.12.

WORKUP

后处理

customThe solution was evaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0293b68f60f54a7180efaf1acee88bff
来源数据集: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05607951
来源说明: uspto-grants-1997_03

反应 SMILES

[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[C:9]1([S:15]([CH2:18][CH2:19][C:20]2[CH:21]=[C:22]3[C:26](=[CH:27][CH:28]=2)[NH:25][CH:24]=[C:23]3[CH2:29][C@H:30]2[CH2:34][CH2:33][CH2:32][N:31]2[CH3:35])(=[O:17])=[O:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(O)C>>[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[C:9]1([S:15]([CH2:18][CH2:19][C:20]2[CH:21]=[C:22]3[C:26](=[CH:27][CH:28]=2)[NH:25][CH:24]=[C:23]3[CH2:29][C@H:30]2[CH2:34][CH2:33][CH2:32][N:31]2[CH3:35])(=[O:17])=[O:16])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1.[C:9]1([S:15]([CH2:18][CH2:19][C:20]2[CH:21]=[C:22]3[C:26](=[CH:27][CH:28]=2)[NH:25][CH:24]=[C:23]3[CH2:29][C@H:30]2[CH2:34][CH2:33][CH2:32][N:31]2[CH3:35])(=[O:17])=[O:16])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1