Ethanol → (R)-5-(2-Benzenesulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole hemisuccinate

Participants

Reaction Steps

A solution of succinic acid (95 mg) in ethanol (5 mL) was added to a solution of (R)-5-(2-benzenesulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole free base (620 mg) in ethanol (5 mL). The solution was evaporated to give the title compound as a foam (680 mg): [α]25D =+29° (methanol, c=0.10). Anal. Calcd for C22H26N2O2S. 0.5 C4H6O4. 0.33 C2H5OH. 0.5 H2O; C, 63.59; H, 6.92; N, 6.01. Found: C, 63.52; H, 6.91; N, 6.12.

Provenance & Evidence