Water → 3-(((2R)-1-Methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethenyl)-1H-indole

HRID 975033Notes

Reaction equation

HRID 975033 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([CH:13]=[CH:14][S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)(=[O:17])=[O:16])=[CH:10][CH:11]=2)[C:6]([CH2:24][C@H:25]2[CH2:29][CH2:28][CH2:27][N:26]2[CH3:30])=[CH:5]1)(=O)C.C(=O)([O-])[O-].[K+].[K+].O>CO>[C:18]1([S:15]([CH:14]=[CH:13][C:9]2[CH:8]=[C:7]3[C:12](=[CH:11][CH:10]=2)[NH:4][CH:5]=[C:6]3[CH2:24][C@H:25]2[CH2:29][CH2:28][CH2:27][N:26]2[CH3:30])(=[O:17])=[O:16])[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 54067212(R)-1-acetyl-5-(benzenesulfonylethenyl)-3-(N-methyl-pyrrolidin-2-ylmethyl)-1H-indole

Product 1

HCID 540753983-(((2R)-1-Methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethenyl)-1H-indoleYield 74.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of (R)-1-acetyl-5-(benzenesulfonylethenyl)-3-(N-methyl-pyrrolidin-2-ylmethyl)-1H-indole (220.8 g) in methanol (2.21 L) was treated with potassium carbonate (72.23 g) and stirred at ambient temperature. After about one hour active carbon (22.1 g) was added to the solution then water (660 mL) added slowly. The mixture was filtered and the filtrate heated to reflux and water (660 mL) added dropwise. The mixture was allowed to cool and crystallize, then further water was added slowly (3.31 l). The resulting solid was filtered, washed with 1:2 methanol:water mixture (2×200 mL) then dried in vacuo to give the title compound (149 g): mp, 84°-87° C. IR (KBr) 1600, 1450, 1290, 1145, 1085 cm-1 : 1H NMR (CDCl3) 8.4 (b, 1H), 8.0 (d, 2H), 7.8 (d, 1H), 7.7 (s, 1H), 7.6-7.5 (m, 3H), 7.3 (s, 2H), 7.05 (b, 1H), 6.75 (d, 1H), 3.15 (m, 2H), 2.6 (m, 1H), 2.45 (s, 3H), 2.4 (s, 1H), 2.2 (m, 1H), 2.0-0.5 (m, 4H); LRMS (TSP), m/z 381, 165, 133, 119.

Workup

  1. additionAfter about one hour active carbon (22.1 g) was added to the solution
  2. filtrationThe mixture was filtered
  3. temperaturethe filtrate heated
  4. temperatureto reflux
  5. additionwater (660 mL) added dropwise
  6. temperatureto cool
  7. customcrystallize
  8. additionfurther water was added slowly (3.31 l)
  9. filtrationThe resulting solid was filtered
  10. washwashed with 1:2 methanol
  11. dry with materialwater mixture (2×200 mL) then dried in vacuo

Sources & evidence

ORD record
ord-f017f0c1414944c383940ac0a7315b9b
Source dataset
uspto-grants-1997_03
Patent number
US05607951

Reaction notes

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