Water → 4-Methyl-2-trifluoroacetyloxazole

HRID 975045Notes

Reaction equation

HRID 975045 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3](N1C=CN=C1)=[O:4].[CH3:12][C:13]1[N:14]=[C:15]([Si](C)(C)C)[O:16][CH:17]=1.O>C(OCC)C>[CH3:12][C:13]1[N:14]=[C:15]([C:3](=[O:4])[C:2]([F:11])([F:10])[F:1])[O:16][CH:17]=1

Participants

5

Reactant 3

HCID 962WaterHCID 737671-(Trifluoroacetyl)imidazoleHCID 131590734-Methyl-2-(trimethylsilyl)-1,3-oxazole

Product 1

HCID 189363124-Methyl-2-trifluoroacetyloxazole

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-Trifluoroacetylimidazole (10 g) was added dropwise to 4-methyl-2-trimethylsilyloxazole (J. Chem. Soc., Chem. Commun., 1984, 258) (9.95 g) in diethyl ether (100 ml) at 0° C. under an atmosphere of dry nitrogen. The mixture was stirred overnight at room temperature. Water was added and the organic layer was separated, washed, dried and evaporated. Flash chromatography gave the title compound.

Workup

  1. customthe organic layer was separated
  2. washwashed
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-8e6d1b93a840438d9b163e266d1031fe
Source dataset
uspto-grants-1997_03
Patent number
US05607956

Reaction notes

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