HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Methyl-2-trifluoroacetyloxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-(Trifluoroacetyl)imidazole | HCID 73767 | — |
| Reactant | 4-Methyl-2-(trimethylsilyl)-1,3-oxazole | HCID 13159073 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-Methyl-2-trifluoroacetyloxazole | HCID 18936312 | — |
Reaction Steps
1-Trifluoroacetylimidazole (10 g) was added dropwise to 4-methyl-2-trimethylsilyloxazole (J. Chem. Soc., Chem. Commun., 1984, 258) (9.95 g) in diethyl ether (100 ml) at 0° C. under an atmosphere of dry nitrogen. The mixture was stirred overnight at room temperature. Water was added and the organic layer was separated, washed, dried and evaporated. Flash chromatography gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607956 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-8e6d1b93a840438d9b163e266d1031fe |
| Source note | uspto-grants-1997_03 |