HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum isopropoxide → Thiazole, 5-(methoxymethyl)-4-methyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum isopropoxide | HCID 11143 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Methylthiazole-5-carboxaldehyde | HCID 581339 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Methyl iodide | HCID 6328 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | Thiazole, 5-(methoxymethyl)-4-methyl- | HCID 11571819 | — |
Reaction Steps
4-Methyl-5-thiazolecarbaldehyde (J. Amer. Chem. Soc., 1982, 104, 4934-4943) was reduced using aluminium isopropoxide in 2-propanol. The resulting alcohol was treated with sodium hydride in dimethoxyethane and iodomethane was added. Distillation gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607956 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-30353ffa3f9544bd8ae183d40ac28cc3 |
| Source note | uspto-grants-1997_03 |