3-Bromothiophene → 1-(2,4-Dimethyl-5-oxazolyl)-1-(3-thienyl)propanol

HRID 975055Notes

Reaction equation

Br[C:2]1[CH:6]=[CH:5][S:4][CH:3]=1.[CH3:7][C:8]1[O:9][C:10]([C:14](=[O:17])[CH2:15][CH3:16])=[C:11]([CH3:13])[N:12]=1>>[CH3:7][C:8]1[O:9][C:10]([C:14]([C:2]2[CH:6]=[CH:5][S:4][CH:3]=2)([OH:17])[CH2:15][CH3:16])=[C:11]([CH3:13])[N:12]=1

Participants

Reactant 2

HCID 133833-Bromothiophene

HCID 189363232,4-Dimethyl-5-propionyloxazole

Product 1

HCID 189363681-(2,4-Dimethyl-5-oxazolyl)-1-(3-thienyl)propanol

Procedure

Starting with 3-bromothiophene and 2,4-dimethyl-5propionyloxazole and following the general method of Example 4 the title compound was prepared. Purification by preparative HPLC gave a white solid. M.p. 81°-83° C.

Sources & evidence

ORD record: ord-c4ee4e346dc946c294b28695aa9cb173
Source dataset: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05607956

Reaction notes

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