5-(3-Hydroxy-1-but-1-enyl)-3-(N-methyl-4-piperidyl)-1H-indole → 5-(3-Hydroxy-1-butyl)-3-(N-methyl-4-piperidyl)-1H-indole

HRID 975145Notes

Reaction equation

HRID 975145 reaction equation
[OH:1][CH:2]([CH3:21])[CH:3]=[CH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH:14]1[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]1>[Pd].C(Cl)Cl>[OH:1][CH:2]([CH3:21])[CH2:3][CH2:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH:14]1[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]1

Participants

4

Reactant 1

HCID 540865635-(3-Hydroxy-1-but-1-enyl)-3-(N-methyl-4-piperidyl)-1H-indole

Product 1

HCID 199709455-(3-Hydroxy-1-butyl)-3-(N-methyl-4-piperidyl)-1H-indole

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6344DichloromethaneSolvent

Procedure

Obtained from the title compound of Example 42 by a procedure similar to that described in Example 2, but using 10% palladium on charcoal as catalyst, as a foam. Rf 0.50 (SS 4). C,73.39; H,8.77; N,9.06. C18H26N2O; 0.125 CH2Cl2 requires C,73.28; H,8.91; N,9.43%.

Sources & evidence

ORD record
ord-631587a7f2de4c9a86ff6b175d215833
Source dataset
uspto-grants-1997_03
Patent number
US05607960

Reaction notes

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