2-Methyl-3-buten-2-ol → 5-(3-Hydroxy-3-methyl-1-but-1-enyl)-3-(2-phthalimidoethyl)-1H-indole

HRID 975147Notes

Reaction equation

HRID 975147 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23].[CH3:24][C:25]([OH:29])([CH:27]=[CH2:28])[CH3:26]>C(Cl)Cl>[OH:29][C:25]([CH3:26])([CH3:24])[CH:27]=[CH:28][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23]

Participants

4

Reactant 2

HCID 82572-Methyl-3-buten-2-olHCID 19970994HCID 19970994, compound

Product 1

HCID 537635265-(3-Hydroxy-3-methyl-1-but-1-enyl)-3-(2-phthalimidoethyl)-1H-indole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Obtained by a procedure similar to that described in Example 1, using 5-bromo-3-(2-phthalimidoethyl)-1H-indole (which was prepared as described in U.S. Pat. No. 4,252,803) and 2-methylbut-3-en-2-ol, as a foam. Rf 0.10 (SS 8). Found: C,72.31; H,6.09; N,.7.16. C23H22N2O3 ; 0.15 CH2Cl2 requires C,71.82; H,5.81; N,7.23%.

Workup

  1. customObtained by a procedure similar to
  2. customwas prepared

Sources & evidence

ORD record
ord-f6b5c56c0f29406aba0d3bda9fbf1fc2
Source dataset
uspto-grants-1997_03
Patent number
US05607960

Reaction notes

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