Methanol → HCID 22870281, compound

HRID 975148Notes

Reaction equation

HRID 975148 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH:17]=[CH:18][C:19](=[O:21])[CH3:20])[CH:15]=2)[NH:10][CH:9]=1.CO>[Pd].C(Cl)Cl>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:17][CH2:18][C:19](=[O:21])[CH3:20])[CH:15]=2)[NH:10][CH:9]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 54069448HCID 54069448, compound

Product 1

HCID 22870281HCID 22870281, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6344DichloromethaneSolvent

Procedure

Obtained from the title compound of Example 49 by a procedure similar to that described in Example 2, but using 10% palladium on charcoal as catalyst, as a foam. [α]D25 +83° (c=0.1, CH3OH). Found: C,71.61; H,8.36; N,9.02. C18H24N2O; 0.20 CH2Cl2 requires C,71.84; H,8.16; N,9.30%. LRMS: m/z 285.3 (M+1)+.

Sources & evidence

ORD record
ord-2589e70868ec4c90845b8f746f67eb54
Source dataset
uspto-grants-1997_03
Patent number
US05607960

Reaction notes

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