Dichloromethane → HCID 22870333, compound

HRID 975158Notes

Reaction equation

HRID 975158 reaction equation
[OH:1][C:2]([C:22]([F:25])([F:24])[F:23])([CH3:21])[CH:3]=[CH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][C@H:15]1[CH2:19][CH2:18][CH2:17][N:16]1[CH3:20].C(Cl)Cl>[Pd].O>[OH:1][C:2]([C:22]([F:25])([F:24])[F:23])([CH3:21])[CH2:3][CH2:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][C@H:15]1[CH2:19][CH2:18][CH2:17][N:16]1[CH3:20]

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 53988253HCID 53988253, compound

Product 1

HCID 22870333HCID 22870333, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

Obtained from the title compound of Example 96 by a procedure similar to that described in Example 2, but using 10% palladium on charcoal as catalyst, as a foam. Rf 0.40 (SS 7). Found: C,59.55; H,6.86; N,7.10. C19H25F3N2O; 0.17 CH2Cl2 ; H2O requires C,59.55; H,7.13; N,7.25%. LRMS: m/z 355.0 (M+1)+.

Sources & evidence

ORD record
ord-12af266f0c0148669b5e64c58ac855d3
Source dataset
uspto-grants-1997_03
Patent number
US05607960

Reaction notes

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