Methanol → HCID 22870332, compound

HRID 975159Notes

Reaction equation

HRID 975159 reaction equation
[OH:1][C:2]([C:27]([F:30])([F:29])[F:28])([CH3:26])[CH:3]=[CH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][C@H:15]1[CH2:19][CH2:18][CH2:17][N:16]1[CH2:20][CH2:21][C:22](=[O:25])[NH:23][CH3:24].CO.C(Cl)Cl>[Pd].O>[OH:1][C:2]([C:27]([F:29])([F:30])[F:28])([CH3:26])[CH2:3][CH2:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][C@H:15]1[CH2:19][CH2:18][CH2:17][N:16]1[CH2:20][CH2:21][C:22](=[O:25])[NH:23][CH3:24]

Participants

6

Reactant 3

HCID 887MethanolHCID 6344DichloromethaneHCID 54126498HCID 54126498, compound

Product 1

HCID 22870332HCID 22870332, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

Obtained from the title compound of Example 98 by a procedure similar to that described in Example 2, but using 10% palladium on charcoal as catalyst, as a foam. Rf 0.45 (SS 7). [α]D25 +39° (c=0.1, CH3OH). Found: C,59.07; H,7.16; N,9.21. C22H30F3N3O2 ; 0.05 CH2Cl2 ; H2O requires C,59.15; H,7.22; N,9.39%. LRMS: m/z 426.4 (M+1)+.

Sources & evidence

ORD record
ord-d4324e6c68b9425e81032eeb01c00a46
Source dataset
uspto-grants-1997_03
Patent number
US05607960

Reaction notes

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