Hydrochloric Acid → 5'-Methanesulfonyl-2',3'-anhydro-5-methyluridine

Participants

Reaction Conditions

Reaction Steps

To a solution of 49 ml 1N sodium hydroxide was added 2',3',5'-tris(methanesulfonyl)-5-methyluridine (2, 6.0 g). The mixture was stirred at 70°-72° C. for 15 minutes and then cooled 0° C. The pH was adjusted to 4 by using concentrated HCl. The resulting slurry was filtered, washed with 2×10 ml water and dried to give 5'-methanesulfonyl-2'-3'-anhydro-5-methyluridine (3), 3.1 g, (84%).

Provenance & Evidence