HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 975187Generated: October 29, 2026
Water → 5'-Benzoyl-2',3'-didehydro-3'-deoxythymidine
https://huagongshe.com/reaction/975187
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Benzoate | HCID 517055 | — |
| Reactant | 5'-Methanesulfonyl-2',3'-didehydro-3'-deoxythymidine | HCID 67575297 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5'-Benzoyl-2',3'-didehydro-3'-deoxythymidine | HCID 67636207 | — |
Reaction Steps
To a mixture of 5'-mesyl-d4T (6, 0.4 g) in 6 ml of DMF was added powdered sodium benzoate (0.24 g). The reaction was stirred at 100° C. for 6 hours. After cooling, water (30 ml) was added. The resulting precipitate was filtered, washed with 2×5 ml water and dried to give 5'-benzoly-d4T (7'), 0.04 g (91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05608049 |
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| Source dataset | uspto-grants-1997_03 |
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| ORD ID | ord-cfb43a28daef4a9488e17da1b7a33d7b |
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| Source note | uspto-grants-1997_03 |
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