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HRID975187

反应详情

EQUATION

反应方程式

HRID 975187 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：O=C([O-])c1ccccc1.[Na+]
HCID517055

Sodium benzoate

C7H5NaO2

结构：Cc1cn([C@H]2C=C[C@@H](C(O)S(C)(=O)=O)O2)c(=O)[nH]c1=O
HCID67575297

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cn([C@H]2C=C[C@@H](C(O)C(=O)c3ccccc3)O2)c(=O)[nH]c1=O
HCID67636207

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

To a mixture of 5'-mesyl-d4T (6, 0.4 g) in 6 ml of DMF was added powdered sodium benzoate (0.24 g). The reaction was stirred at 100° C. for 6 hours. After cooling, water (30 ml) was added. The resulting precipitate was filtered, washed with 2×5 ml water and dried to give 5'-benzoly-d4T (7'), 0.04 g (91%).

WORKUP

后处理

  1. temperatureAfter cooling
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with 2×5 ml water
  4. customdried
  5. customto give 5'-benzoly-d4T (7'), 0.04 g (91%)