1,2-Dibromoethane → 2-methoxyacetophenone O-(2-bromoethyl)oxime

Participants

Reaction Steps

A mixture of the above oxime (5.5 g, 33 mmol), 1,2-dibromoethane (50 ml), potassium carbonate (12.4 g, 90 mmol) and acetone (100 ml) was heated at reflux for 24 h. The mixture was filtered and the solvent was evaporated from the filtrate in vacuo. The residue was purified by column chromatography on silica gel (80 g, n-heptane/ethyl acetate 20/1) to give 6.6 g of 2-methoxyacetophenone O-(2-bromoethyl)oxime.

Provenance & Evidence