反应详情

A mixture of the above oxime (5.5 g, 33 mmol), 1,2-dibromoethane (50 ml), potassium carbonate (12.4 g, 90 mmol) and acetone (100 ml) was heated at reflux for 24 h. The mixture was filtered and the solvent was evaporated from the filtrate in vacuo. The residue was purified by column chromatography on silica gel (80 g, n-heptane/ethyl acetate 20/1) to give 6.6 g of 2-methoxyacetophenone O-(2-bromoethyl)oxime.

1. temperaturewas heated
2. temperatureat reflux for 24 h
3. filtrationThe mixture was filtered
4. customthe solvent was evaporated from the filtrate in vacuo
5. customThe residue was purified by column chromatography on silica gel (80 g, n-heptane/ethyl acetate 20/1)