1,2-Dibromoethane → HCID 54141287, compound

HRID 975244Notes

Reaction equation

HRID 975244 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3](=[N:10][OH:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[Br:14][CH2:15][CH2:16]Br.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:14][CH2:15][CH2:16][O:11][N:10]=[C:3]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:2]([F:12])([F:13])[F:1]

Participants

5

Reactant 3

HCID 78391,2-DibromoethaneHCID 11430Potassium CarbonateHCID 604931655-25-4

Product 1

HCID 54141287HCID 54141287, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of the above oxime (13.5 g, 71 mmol), 1,2-dibromoethane (65 ml), potassium carbonate (29.4 g, 213 mmol) and acetone (100 ml) was heated at reflux for 16 h and then stirred at room temperature for 7 days. The mixture was filtered and the solvent was evaporated from the filtrate in vacuo to give 20.7 g of 2,2,2-trifluoroacetophenone O-(2-bromoethyl)oxime.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 16 h
  3. filtrationThe mixture was filtered
  4. customthe solvent was evaporated from the filtrate in vacuo

Sources & evidence

ORD record
ord-dc59dd1b89134c8babf0dc24f1daf85e
Source dataset
uspto-grants-1997_03
Patent number
US05608069

Reaction notes

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