Ethanol → 1,2-Bis(4-fluorophenyl)-2-hydroxyethanone

HRID 975262Notes

Reaction equation

HRID 975262 reaction equation
[C-]#N.[K+].[F:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1.[CH2:13]([OH:15])[CH3:14]>O>[OH:15][CH:13]([C:14]1[CH:11]=[CH:12][C:5]([F:4])=[CH:6][CH:7]=1)[C:9]([C:8]1[CH:11]=[CH:12][C:5]([F:4])=[CH:6][CH:7]=1)=[O:10]

Participants

5

Reactant 3

HCID 702EthanolHCID 9032Potassium CyanideHCID 680234-Fluorobenzaldehyde

Product 1

HCID 1037861,2-Bis(4-fluorophenyl)-2-hydroxyethanone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of potassium cyanide (2.0 g, 31 mmol), 4-fluorobenzaldehyde, 96% ethanol (30 ml) and water (30 ml) was heated at reflux for 0.5 h and then kept at 5° C. for 72 h. The precipitated compound was collected and recrystallised from ethanol/water to give 20 g of 2-hydroxy-1,2-bis(4-fluorophenyl)ethanone.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 0.5 h
  3. customThe precipitated compound was collected
  4. customrecrystallised from ethanol/water

Sources & evidence

ORD record
ord-3f5932054457449ca31682f248b823da
Source dataset
uspto-grants-1997_03
Patent number
US05608069

Reaction notes

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