Ethanol → HCID 19971657, compound

HRID 975266Notes

Reaction equation

HRID 975266 reaction equation
[C-]#N.[K+].[F:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8].[CH2:13]([OH:15])[CH3:14]>O>[OH:15][CH:13]([C:14]1[CH:11]=[CH:10][CH:9]=[CH:6][C:5]=1[F:4])[C:7]([C:6]1[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=1[F:4])=[O:8]

Participants

5

Reactant 3

HCID 702EthanolHCID 9032Potassium CyanideHCID 67970o-Fluorobenzaldehyde

Product 1

HCID 19971657HCID 19971657, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of potassium cyanide (2.0 g, 31 mmol), 2-fluorobenzaldehyde (26 g, 21 mmol), ethanol (30 ml) and water (30 ml) was heated at reflux for 1.5 h and then kept at -15° C. for 2 h. The precipitated compound was collected to give 20 g of 2-hydroxy-1,2-bis(2-fluorophenyl)ethanone.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1.5 h
  3. customThe precipitated compound was collected

Sources & evidence

ORD record
ord-2c8db5efcef7411587c587b9b9348ae3
Source dataset
uspto-grants-1997_03
Patent number
US05608069

Reaction notes

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