Hydrochloric Acid → HCID 54566831, compound

A solution of (2R,4R)-1-allyloxycarbonyl-4-(t-butyldimethylsilyloxy)-2-(2-hydroxyethyl)pyrrolidine (5.0 g) and conc. hydrochloric acid (2.53 ml) in methanol (25 ml) was stirred under ice-cooling for 10 minutes and then stirred at ambient temperature for 1 hour. To the reaction mixture cooled at 0° C. was added 28% sodium methoxide in methanol solution (5.84 ml). The resulting precipitates were filtered off and the filtrate was evaporated in vacuo to give a residue. The residue was dissolved in dichloromethane (15 ml) and the solution was dried over anhydrous magnesium sulfate and evaporated in vacuo to give a residue. The residue was washed with n-hexane and dried in vacuo to give (2R,4R)-1-allyloxycarbonyl-4-hydroxy-2-(2-hydroxyethyl)pyrrolidine (3.10 g).

1. temperaturecooling for 10 minutes
2. temperatureTo the reaction mixture cooled at 0° C.
3. customThe resulting precipitates
4. filtrationwere filtered off
5. customthe filtrate was evaporated in vacuo
6. customto give a residue
7. dry with materialthe solution was dried over anhydrous magnesium sulfate
8. customevaporated in vacuo
9. customto give a residue
10. washThe residue was washed with n-hexane
11. customdried in vacuo

ORD record

ord-9cfe794c2bce45c6b90a4032ea7dd3a2

Source dataset

uspto-grants-1997_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05608056