Ammonium Chloride → HCID 67705500, compound

HRID 975693Notes

Reaction equation

[CH2:1]([O:4][C:5]([N:7]1[CH2:11][C@@H:10]([S:12][C:13]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:9][C@@H:8]1[CH2:32][C:33](=[NH:36])SC)=[O:6])[CH:2]=[CH2:3].[Cl-:37].[NH4+:38]>CO>[ClH:37].[CH2:1]([O:4][C:5]([N:7]1[CH2:11][C@@H:10]([S:12][C:13]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:9][C@H:8]1[CH2:32][C:33](=[NH:36])[NH2:38])=[O:6])[CH:2]=[CH2:3]

Participants

Conditions

Temperature: 50 °C

Procedure

To a solution of (2R,4S)-1-allyloxycarbonyl-2-(2-imino-2-methylthioethyl)-4-(triphenylmethylthio)pyrrolidine (1.95 g) in methanol (39 ml) was added ammonium chloride (222 mg). After stirring at 50° C. for 2 hours, the solution was evaporated under reduced pressure. The residue was triturated with diisopropyl ether to give (2R,4S)-1-allyloxycarbonyl-2-amidinomethyl-4-(triphenylmethylthio)pyrrolidine hydrochloride (1.36 g).

Workup

customthe solution was evaporated under reduced pressure
customThe residue was triturated with diisopropyl ether

Sources & evidence

ORD record: ord-eab7cfd813e44775aa1a4db06447a2b9
Source dataset: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05608056

Reaction notes

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