HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → (2R,4S)-1-allyloxycarbonyl-4-acetylthio-2-[2-(4-cyanoimidazol-1-yl)ethyl]pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | (2R,4R)-1-Allyloxycarbonyl-2-[2-(4-cyanoimidazol-1-yl) ethyl]-4-methanesulfonyloxypyrrolidine | HCID 53735347 | — |
| Reactant | HCID 178418634 | HCID 178418634 | — |
| Product | (2R,4S)-1-allyloxycarbonyl-4-acetylthio-2-[2-(4-cyanoimidazol-1-yl)ethyl]pyrrolidine | HCID 53670605 | — |
Reaction Steps
(2R,4R)-1-Allyloxycarbonyl-2-[2-(4-cyanoimidazol-1-yl) ethyl]-4-methanesulfonyloxypyrrolidine (13.4 g) was reacted with thioacetic acid (5.46 ml) and potassium t-butoxide (8.17 g) in substantially the same manner as Preparation 4-12) to give (2R,4S)-1-allyloxycarbonyl-4-acetylthio-2-[2-(4-cyanoimidazol-1-yl)ethyl]pyrrolidine (12.5 g) as a yellow paste.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05608056 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-e16d1bd705874bac95da9d1443059454 |
| Source note | uspto-grants-1997_03 |