反应详情

The resulting cyclohexane derivative was dissolved in a mixed solvent of acetone (80 ml) with 2N hydrochloric acid (8 ml), followed by heating the solution under reflux for 4 hours, cooling the reaction mixture down to room temperature after completion of the stirring, adding water, extracting with ether (50 ml), drying the organic layer over anhydrous magnesium sulfate, and concentrating under reduced pressure to obtain 3-(4-(4-propylcyclohexyl)cyclohexyl)-2E-propenal (3.1 g, 12 mmols). This product was used in the subsequent reaction without any purification.

1. temperatureby heating the solution
2. temperatureunder reflux for 4 hours
3. extractionextracting with ether (50 ml)
4. dry with materialdrying the organic layer over anhydrous magnesium sulfate
5. concentrationconcentrating under reduced pressure