HuagongsheHuagongshe Chemistry Print Report · For research reference only
11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → 5,11-Dihydro-11-[[3-[3-[(benzoyl)methylamino]propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one | HCID 120053 | — |
| Reactant | 3-[3-[(Benzoyl)methylamino]-propyl]piperidine | HCID 19039430 | — |
| Product | 5,11-Dihydro-11-[[3-[3-[(benzoyl)methylamino]propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 19039392 | — |
Reaction Steps
Prepared analogously to Example 8 from 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one and 3-[3-[(benzoyl)methylamino]-propyl]piperidine. Purification is carried out by chromatography on silica gel using a mixture of methylene chloride/methanol=99:1 as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05610155 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-606fde0e3ddc4e439e008f4fe9553bc1 |
| Source note | uspto-grants-1997_03 |